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Neurodevelopmental Physiology Laboratory (Takae Hirasawa Laboratory)
Neurodevelopmental Physiology Laboratory
(Takae Hirasawa Laboratory)

Takae Hirasawa

Our laboratory specializes in neuroscience, and conducts animal-based lectures and practical training in developmental biology, basic neuroscience, and behavioral neurology. In the graduation research, students learn nerve cell culture techniques, staining methods, protein analysis, and gene analysis techniques using the mouse brain and also learn the technique of analyzing neural function. It is very exciting to observe the dynamics of active nerve cells and the glial cells that surround them. We are also aiming to develop the mechanism of brain function and disease treatment with other laboratories and research institutes.

Basic Information

Faculty name/Affiliation Takae Hirasawa / Department of Biosciences Faculty of Science and Engineering
Specialized Fields Neuroscience
Research theme Study on the mechanism of how environmental factors such as mental stress and child-rearing in early childhood and fetal period affect brain function development after maturity
Research keywords Brain function development, gene regulation mechanism, environmental factors
Faculty introduction URL https://www3.med.teikyo-u.ac.jp/profile/ja.80c34158c88bd937.html

Our Research

About the microglial activation control mechanism caused by mental stress in early childhood

In addition to nerve cells, the cells that make up the brain include glial cells, which regulate nerve function. We are investigating the regulatory mechanism of microglial cells that control intracerebral immunity. In particular, we are investigating the mechanism by which mental stress in the early postnatal period affects the properties and functions of microglia.

The activated regulation of microglia in juvenile mental stress

The brain contains the other cells called a glia cells not only neurons. We investigate the regulatory mechanism of microglia cells involved in brain immunity. In this study, we focus the effects of the activity and function of microglia in juvenile mental stress, for example, maternal separation stress.

Synaptic abnormalities in Glp knockout mice, which are autism model mice

Kleefstra syndrome (KS) is a congenital malformative syndrome with mental retardation, mainly due to autism and the main cause of mutations in the histone methyltransferase EHMT1 / GLP gene. In this study, we research neurological analysis using Glp hetero KO mice, which is a KS model.

Synaptic dysfunction in the Glp Knockout mouse model of autistic model mouse.

Kleefstra syndrome (KS) is genetic mental disorder as autistic symptom. EHMT1 / GLP is the responsible gene in this syndrome, which cause heterogyzous mutant. EHMT1 / GLP protein encoded H3K9me, which represent a specific tag for epigenetic tanscriptional repression. In this study, we elucidate the neurological analysis in Glp Knock out (KO) mouse brain.

Conference presentation

Conference presentation

Title Society name Laboratory Contents
Temperature-dependent sexual differentiation mechanism in Japanese eel (Anguilla) The 44th The Molecular Biology Society of Japan Neurodevelopmental Physiology Laboratory detail

Title Society name Laboratory Contents
Ubiquitin control system-related molecule PA28γ regulates neural function of cerebellar Purkinje cells
Proteasome Activator PA28 gamma regulate neuronal function of cerebellar Purkinje cells
The Molecular Biology Society of Japan Neurodevelopmental Physiology Laboratory detail

Introducing the FacultyThis section introduces details about the research and the passionate thoughts around the research.

Introduction of Associate Professor Takae Hirasawa

Discover the fascinating and untold stories behind the cutting-edge research being conducted by our esteemed professors. Get an in-depth look at the motivations and passions driving their work, and learn how their findings are making a real impact on society. Don't miss the opportunity to gain a deeper understanding of the amazing work being done right here at our laboratory!

Introduction of Takae Hirasawa