Our laboratory specializes in neuroscience, and conducts animal-based lectures and practical training in developmental biology, basic neuroscience, and behavioral neurology. In the graduation research, students learn nerve cell culture techniques, staining methods, protein analysis, and gene analysis techniques using the mouse brain and also learn the technique of analyzing neural function. It is very exciting to observe the dynamics of active nerve cells and the glial cells that surround them. We are also aiming to develop the mechanism of brain function and disease treatment with other laboratories and research institutes.
Basic Information
Faculty name/Affiliation
Takae Hirasawa / Department of Biosciences Faculty of Science and Engineering
Specialized Fields
Neuroscience
Research theme
Study on the mechanism of how environmental factors such as mental stress and child-rearing in early childhood and fetal period affect brain function development after maturity
Research keywords
Brain function development, gene regulation mechanism, environmental factors
About the microglial activation control mechanism caused by mental stress in early childhood
In addition to nerve cells, the cells that make up the brain include glial cells, which regulate nerve function. We are investigating the regulatory mechanism of microglial cells that control intracerebral immunity. In particular, we are investigating the mechanism by which mental stress in the early postnatal period affects the properties and functions of microglia.
The activated regulation of microglia in juvenile mental stress
The brain contains the other cells called a glia cells not only neurons. We investigate the regulatory mechanism of microglia cells involved in brain immunity. In this study, we focus the effects of the activity and function of microglia in juvenile mental stress, for example, maternal separation stress.
Synaptic abnormalities in Glp knockout mice, which are autism model mice
Kleefstra syndrome (KS) is a congenital malformative syndrome with mental retardation, mainly due to autism and the main cause of mutations in the histone methyltransferase EHMT1 / GLP gene. In this study, we research neurological analysis using Glp hetero KO mice, which is a KS model.
Synaptic dysfunction in the Glp Knockout mouse model of autistic model mouse.
Kleefstra syndrome (KS) is genetic mental disorder as autistic symptom. EHMT1 / GLP is the responsible gene in this syndrome, which cause heterogyzous mutant. EHMT1 / GLP protein encoded H3K9me, which represent a specific tag for epigenetic tanscriptional repression. In this study, we elucidate the neurological analysis in Glp Knock out (KO) mouse brain.
Conference presentation
Conference presentation
Title
Society name
Laboratory
Contents
Temperature-dependent sexual differentiation mechanism in Japanese eel (Anguilla)
Ubiquitin control system-related molecule PA28γ regulates neural function of cerebellar Purkinje cells Proteasome Activator PA28 gamma regulate neuronal function of cerebellar Purkinje cells
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